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909 Joosten, M. M., Beulens, J. W. J., Kersten, S., & Hendriks, H. F. J. (2008). Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial. Diabetologia, 51(8), 1375–1381. doi:10.1007/s00125-008-1031-y

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912 Rosique-Esteban, N., Guasch-Ferré, M., Hernández-Alonso, P., & Salas-Salvadó, J. (2018). Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies. Nutrients, 10(2), 168. doi:10.3390/nu10020168

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914 Veronese, N., Watutantrige-Fernando, S., Luchini, C., Solmi, M., Sartore, G., Sergi, G., Manzato, E., Barbagallo, M., Maggi, S., & Stubbs, B. (2016). Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials. European journal of clinical nutrition, 70(12), 1354–1359. URL: https://doi.org/10.1038/ejcn.2016.154

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917 Veech, R. L., Bradshaw, P. C., Clarke, K., Curtis, W., Pawlosky, R., & King, M. T. (2017). Ketone bodies mimic the life span extending properties of caloric restriction. IUBMB Life, 69(5), 305–314. doi:10.1002/iub.1627

918 Elamin, M., Ruskin, D. N., Masino, S. A., & Sacchetti, P. (2017). Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism? Frontiers in Molecular Neuroscience, 10. doi:10.3389/fnmol.2017.00377

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921 Gao, J., Feng, Z., Wang, X., Zeng, M., Liu, J., Han, S., … Liu, J. (2017). SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death & Differentiation, 25(2), 229–240. doi:10.1038/cdd.2017.144

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934 Mason, S. A., Della Gatta, P. A., Snow, R. J., Russell, A. P., & Wadley, G. D. (2016). Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study. Free Radical Biology and Medicine, 93, 227–238. doi:10.1016/j.freeradbiomed.2016.01.006

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947 Hyde, P. N., Sapper, T. N., Crabtree, C. D., LaFountain, R. A., Bowling, M. L., Buga, A., … Volek, J. S. (2019). Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss. JCI Insight, 4(12). doi:10.1172/jci.insight.128308

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953 Milder, J. B., Liang, L. P., & Patel, M. (2010). Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet. Neurobiology of disease, 40(1), 238–244. URL: https://doi.org/10.1016/j.nbd.2010.05.030

954 Jarrett, S. G., Milder, J. B., Liang, L. P., & Patel, M. (2008). The ketogenic diet increases mitochondrial glutathione levels. Journal of neurochemistry, 106(3), 1044–1051. URL: https://doi.org/10.1111/j.1471–4159.2008.05460.x

955 Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., Newgard, C. B., Farese, R. V., Jr, de Cabo, R., Ulrich, S., Akassoglou, K., & Verdin, E. (2013). Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, N.Y.), 339(6116), 211–214. URL: https://doi.org/10.1126/science.1227166

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957 Miller, V. J., Villamena, F. A., & Volek, J. S. (2018). Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health. Journal of Nutrition and Metabolism, 2018, 1–27. doi:10.1155/2018/5157645

958 NISHIMUTA, M., KODAMA, N., YOSHITAKE, Y., SHIMADA, M., & SERIZAWA, N. (2018). Dietary Salt (Sodium Chloride) Requirement and Adverse Effects of Salt Restriction in Humans. Journal of Nutritional Science and Vitaminology, 64(2), 83–89. doi:10.3177/jnsv.64.83

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960 Kinzig, K. P., Honors, M. A., & Hargrave, S. L. (2010). Insulin sensitivity and glucose tolerance are altered by maintenance on a ketogenic diet. Endocrinology, 151(7), 3105–3114. URL: https://doi.org/10.1210/en.2010-0175

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973 Lomenick, J. P., Melguizo, M. S., Mitchell, S. L., Summar, M. L., & Anderson, J. W. (2009). Effects of meals high in carbohydrate, protein, and fat on ghrelin and peptide YY secretion in prepubertal children. The Journal of clinical endocrinology and metabolism, 94(11), 4463–4471. URL: https://doi.org/10.1210/jc.2009-0949

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988 Nancy R Rodriguez, Introduction to Protein Summit 2.0: continued exploration of the impact of high-quality protein on optimal health, The American Journal of Clinical Nutrition, Volume 101, Issue 6, June 2015, Pages 1317S–1319S, URL: https://doi.org/10.3945/ajcn.114.083980

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997 Casas, R., Sacanella, E., & Estruch, R. (2014). The Immune Protective Effect of the Mediterranean Diet against Chronic Low-grade Inflammatory Diseases. Endocrine, Metabolic & Immune Disorders-Drug Targets, 14(4), 245–254. doi:10.2174/1871530314666140922153350

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1029 ROBERTS H. J. (1964). AFTERNOON GLUCOSE TOLERANCE TESTING: A KEY TO THE PATHOGENESIS, EARLY DIAGNOSIS AND PROGNOSIS OF DIABETOGENIC HYPERINSULINISM. Journal of the American Geriatrics Society, 12, 423–472. URL: https://doi.org/10.1111/j.1532–5415.1964.tb05730.x

1030 Ramracheya, R. D., Muller, D. S., Squires, P. E., Brereton, H., Sugden, D., Huang, G. C., Amiel, S. A., Jones, P. M., & Persaud, S. J. (2008). Function and expression of melatonin receptors on human pancreatic islets. Journal of pineal research, 44(3), 273–279. URL: https://doi.org/10.1111/j.1600-079X.2007.00523.x

1031 Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F., & Dela, F. (2004). Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes, 53(2), 294–305. URL: https://doi.org/10.2337/diabetes.53.2.294

1032 Boden, G., Ruiz, J., Urbain, J. L., & Chen, X. (1996). Evidence for a circadian rhythm of insulin secretion. The American journal of physiology, 271(2 Pt 1), E246–E252. URL: https://doi.org/10.1152/ajpendo.1996.271.2.E246

1033 Saad, A., Dalla Man, C., Nandy, D. K., Levine, J. A., Bharucha, A. E., Rizza, R. A., Basu, R., Carter, R. E., Cobelli, C., Kudva, Y. C., & Basu, A. (2012). Diurnal pattern to insulin secretion and insulin action in healthy individuals. Diabetes, 61(11), 2691–2700. URL: https://doi.org/10.2337/db11-1478

1034 Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A., & Scheer, F. A. (2015). Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proceedings of the National Academy of Sciences of the United States of America, 112(17), E2225– E2234. URL: https://doi.org/10.1073/pnas.1418955112

1035 Pulimeno, P., Mannic, T., Sage, D., Giovannoni, L., Salmon, P., Lemeille, S., GiryLaterriere, M., Unser, M., Bosco, D., Bauer, C., Morf, J., Halban, P., Philippe, J., & Dibner, C. (2013). Autonomous and self-sustained circadian oscillators displayed in human islet cells. Diabetologia, 56(3), 497–507. URL: https://doi.org/10.1007/s00125-012-2779-7

1036 Qian, J., Block, G. D., Colwell, C. S., & Matveyenko, A. V. (2013). Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes, 62(10), 3469–3478. URL: https://doi.org/10.2337/db12-1543

1037 Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., Lopez, J. P., Philipson, L. H., Bradfield, C. A., Crosby, S. D., JeBailey, L., Wang, X., Takahashi, J. S., & Bass, J. (2010). Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature, 466(7306), 627–631. URL: https://doi.org/10.1038/nature09253

1038 Wolff, G., & Esser, K. A. (2012). Scheduled exercise phase shifts the circadian clock in skeletal muscle. Medicine and science in sports and exercise, 44(9), 1663–1670. URL: https://doi.org/10.1249/MSS.0b013e318255cf4c

1039 Srikanthan, P. and Karlamangla, AS. (2011) 'Relative Muscle Mass Is Inversely Associated with Insulin Resistance and Prediabetes. Findings from The Third National Health and Nutrition Examination Survey', The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 9, 1 September 2011, Pages 2898–2903.

1040 Reiser Raymond (1973). "Saturated fat in the diet and serum cholesterol concentration: a critical examination of the literature" (PDF). Am J Clin Nutr. 26: 524–555.

1041 Harcombe, Z., Baker, J. S., DiNicolantonio, J. J., Grace, F., & Davies, B. (2016). Evidence from randomised controlled trials does not support current dietary fat guidelines: a systematic review and meta-analysis. Open Heart, 3(2), e000409. doi:10.1136/openhrt- 2016-000409

1042 Harcombe, Z., Baker, J. S., Cooper, S. M., Davies, B., Sculthorpe, N., DiNicolantonio, J. J., & Grace, F. (2015). Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and metaanalysis. Open Heart, 2(1), e000196. doi:10.1136/openhrt-2014-000196

1043 Siri-Tarino PW с соавторами (2010) 'Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease', Am J Clin Nutr. 2010 Mar;91(3):535-46.

1044 Wakai, K. с соавторами 'Dietary intakes of fat and total mortality among Japanese populations with a low fat intake: the Japan Collaborative Cohort (JACC) Study', Nutr Metab (Lond). 2014; 11: 12.

1045 Guasch-Ferré, M., Hu, F. B., Martínez-González, M. A., Fitó, M., Bulló, M., Estruch, R., … Salas-Salvadó, J. (2014). Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study. BMC Medicine, 12(1). doi:10.1186/1741-7015-12-78

1046 Nocella, C., Cammisotto, V., Fianchini, L., D'Amico, A., Novo, M., Castellani, V., Stefanini, L., Violi, F., & Carnevale, R. (2018). Extra Virgin Olive Oil and Cardiovascular Diseases: Benefits for Human Health. Endocrine, metabolic & immune disorders drug targets, 18(1), 4–13. URL: https://doi.org/10.2174/1871530317666171114121533

1047 Simopoulos, A. P., & DiNicolantonio, J. J. (2016). The importance of a balanced ω-6 to ω-3 ratio in the prevention and management of obesity. Open Heart, 3(2), e000385. doi:10.1136/openhrt-2015-000385

1048 DiNicolantonio, J. J., & O’Keefe, J. H. (2018). Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis. Open Heart, 5(2), e000898. doi:10.1136/openhrt-2018-000898

1049 DiNicolantonio, J. J., & O’Keefe, J. H. (2018). Importance of maintaining a low omega–6/omega–3 ratio for reducing inflammation. Open Heart, 5(2), e000946. doi:10.1136/openhrt-2018-000946

1050 Soysal, P., Arik, F., Smith, L., Jackson, S. E., & Isik, A. T. (2020). Inflammation, Frailty and Cardiovascular Disease. Frailty and Cardiovascular Diseases, 55–64. doi:10.1007/978-3-030-33330-0_7

1051 Willerson, J. T. (2004). Inflammation as a Cardiovascular Risk Factor. Circulation, 109(21_suppl_1), II–2–II–10. doi:10.1161/01.cir.0000129535.04194.38

1052 RAHEJA, B. S., SADIKOT, S. M., PHATAK, R. B., & RAO, M. B. (1993). Significance of the N-6/N-3 Ratio for Insulin Action in Diabetes. Annals of the New York Academy of Sciences, 683(1 Dietary Lipid), 258–271. doi:10.1111/j.1749–6632.1993.tb35715.x

1053 Simopoulos, A. P., & DiNicolantonio, J. J. (2016). The importance of a balanced ω-6 to ω-3 ratio in the prevention and management of obesity. Open Heart, 3(2), e000385. doi:10.1136/openhrt-2015-000385

1054 Calder, P. C. (2009). Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale. Biochimie, 91(6), 791–795. doi:10.1016/j.biochi.2009.01.008

1055 Keys A, с соавторами (1963) 'CORONARY HEART DISEASE AMONG MINNESOTA BUSINESS AND PROFESSIONAL MEN FOLLOWED FIFTEEN YEARS', Circulation 1963 Sep;28:381-95.

1056 Ancel Keys (ed), Seven Countries: A multivariate analysis of death and coronary heart disease, 1980. Cambridge, Mass.: Harvard University Press.

1057 KEYS A. (1953). Atherosclerosis: a problem in newer public health. Journal of the Mount Sinai Hospital, New York, 20(2), 118–139.

1058 Yerushalmy, J., & Hilleboe, H. (1957). Fat in the diet and mortality from heart disease; a methodologic note. New York state journal of medicine, 57 14, 2343-54.

1059 Pett, Kahn, Willett, Katz (2017). "Ancel Keys and the Seven Countries Study: An Evidence-based Response to Revisionist Histories" (PDF). True Health Initiative.

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1061 Katz LN, Keys A, Gofman JW (1952). "Atherosclerosis. A Symposium: Introduction"(PDF). Circulation. 5: 98–100.

1062 AHRENS, E. H., Jr, BLANKENHORN, D. H., & TSALTAS, T. T. (1954). Effect on human serum lipids of substituting plant for animal fat in diet. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 86(4), 872–878. URL: https://doi.org/10.3181/00379727-86-21260

1063 Ahrens, E., Insull, W., Blomstrand, R., Hirsch, J., Tsaltas, T., & Peterson, M. (1957). THE INFLUENCE OF DIETARY FATS ON SERUM-LIPID LEVELS IN MAN. The Lancet, 269(6976), 943–953. doi:10.1016/s0140-6736(57)91280-1

1064 Yudkin, J. (1964). DIETARY FAT AND DIETARY SUGAR IN RELATION TO ISCHÆMIC HEART-DISEASE AND DIABETES. The Lancet, 284(7349), 4–5. doi:10.1016/s0140-6736(64)90002-9

1065 Sarwar, N., Danesh, J., Eiriksdottir, G., Sigurdsson, G., Wareham, N., Bingham, S., … Gudnason, V. (2007). Triglycerides and the Risk of Coronary Heart Disease. Circulation, 115(4), 450–458. doi:10.1161/circulationaha.106.637793

1066 Hooper, L., Martin, N., Jimoh, O. F., Kirk, C., Foster, E., & Abdelhamid, A. S. (2020). Reduction in saturated fat intake for cardiovascular disease. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd011737.pub2

1067 Ramsden, C. E., Hibbeln, J. R., & Majchrzak-Hong, S. F. (2011). All PUFAs Are Not Created Equal: Absence of CHD Benefit Specific to Linoleic Acid in Randomized Controlled Trials and Prospective Observational Cohorts. Healthy Agriculture, Healthy Nutrition, Healthy People, 30–43. doi:10.1159/000327789

1068 Blasbalg, T. L., Hibbeln, J. R., Ramsden, C. E., Majchrzak, S. F., & Rawlings, R. R. (2011). Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. The American Journal of Clinical Nutrition, 93(5), 950–962. doi:10.3945/ajcn.110.006643

1069 Nair U с соавторами (2007) 'Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: a review of published adduct types and levels in humans', Free Radic Biol Med. 2007 Oct 15;43(8):1109-20.

1070 Ghosh S с соавторами (2007) 'Cardiac proinflammatory pathways are altered with different dietary n-6 linoleic to n-3 α-linolenic acid ratios in normal, fat-fed pigs', American Journal of Physiology-Heart and Circulatory Physiology 2007 293:5, H2919-H2927.

1071 Harvard T.H. Chan, The Nutrition Source, 'Omega-3 Fatty Acids: An Essential Contribution', Accessed Online: URL: https://www.hsph.harvard.edu/nutritionsource/whatshould-you-eat/fats-and-cholesterol/types-of-fat/omega-3-fats/

1072 Gutiérrez, S., Svahn, S. L., & Johansson, M. E. (2019). Effects of Omega-3 Fatty Acids on Immune Cells. International Journal of Molecular Sciences, 20(20), 5028. doi:10.3390/ijms20205028

1073 Burdge, G. C., & Wootton, S. A. (2002). Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. British Journal of Nutrition, 88(4), 411–420. doi:10.1079/bjn2002689

1074 Garg, A (1998) 'High-monounsaturated-fat diets for patients with diabetes mellitus: a meta-analysis', Am J Clin Nutr. 1998 Mar;67(3 Suppl):577S-582S.

1075 Finucane, OM с соавторами (2015) 'Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity', Diabetes. 2015 Jun;64(6):2116-28.

1076 DiNicolantonio, J. J., & O’Keefe, J. H. (2018). Importance of maintaining a low omega–6/omega–3 ratio for reducing inflammation. Open Heart, 5(2), e000946. doi:10.1136/openhrt-2018-000946

1077PM Kris-Etherton, Denise Shaffer Taylor, Shaomei Yu-Poth, Peter Huth, Kristin Moriarty, Valerie Fishell, Rebecca L Hargrove, Guixiang Zhao, Terry D Etherton; Polyunsaturated fatty acids in the food chain in the United States, The American Journal of Clinical Nutrition, Volume 71, Issue 1, 1 January 2000, Pages 179S–188S.

1078 Leaf A and Weber PC (1988) 'Cardiovascular effects of n-3 fatty acids', AGRIS, Accessed: http://agris.fao.org/agris-search/search.do?recordID=US8845581.

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1080 Simopoulos (1999) 'Essential fatty acids in health and chronic disease 1,2', American Journal of Clinical Nutrition 70(3 Suppl):560S-569S

1081 Hiza, HAB and Bente L (2007) 'Nutrient Content of the U.S. Food Supply, 1909–2004, A Summary Report', Center for Nutrition Policy and Promotion, Home Economics Research Report No. 57.

1082 DiNicolantonio, J. J., & O’Keefe, J. H. (2018). Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis. Open Heart, 5(2), e000898. doi:10.1136/openhrt-2018-000898

1083 Hodgson, J. M., Wahlqvist, M. L., Boxall, J. A., & Balazs, N. D. (1993). Can linoleic acid contribute to coronary artery disease? The American Journal of Clinical Nutrition, 58(2), 228–234. doi:10.1093/ajcn/58.2.228

1084 Best, K. P., Gold, M., Kennedy, D., Martin, J., & Makrides, M. (2016). Omega-3 longchain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials. The American Journal of Clinical Nutrition, 103(1), 128–143. doi:10.3945/ajcn.115.111104

1085 Guyenet, S. J., & Carlson, S. E. (2015). Increase in Adipose Tissue Linoleic Acid of US Adults in the Last Half Century. Advances in Nutrition, 6(6), 660–664. doi:10.3945/an.115.009944

1086 DiNicolantonio, J. J., & O’Keefe, J. H. (2018). Importance of maintaining a low omega–6/omega–3 ratio for reducing inflammation. Open Heart, 5(2), e000946. doi:10.1136/openhrt-2018-000946

1087 Yang, C. W., Lee, Y. Z., Hsu, H. Y., Shih, C., Chao, Y. S., Chang, H. Y., & Lee, S. J. (2017). Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity. Scientific reports, 7(1), 4105. URL: https://doi.org/10.1038/s41598-017-04203-9

1088 DiNicolantonio, J. J., & OKeefe, J. (2019). Importance of maintaining a low omega- 6/omega-3 ratio for reducing platelet aggregation, coagulation and thrombosis. Open Heart, 6(1), e001011. doi:10.1136/openhrt-2019-001011

1089 Cooper, I. D., Crofts, C. A. P., DiNicolantonio, J. J., Malhotra, A., Elliott, B., Kyriakidou, Y., & Brookler, K. H. (2020). Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management. Open Heart, 7(2), e001356. doi:10.1136/openhrt-2020-001356

1090 Chen, H., Wang, S., Zhao, Y., Luo, Y., Tong, H., & Su, L. (2018). Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials. Nutrition Journal, 17(1). doi:10.1186/s12937- 018-0356-8

1091 Körner, A., Schlegel, M., Theurer, J., Frohnmeyer, H., Adolph, M., Heijink, M., … Mirakaj, V. (2017). Resolution of inflammation and sepsis survival are improved by dietary Ω-3 fatty acids. Cell Death & Differentiation, 25(2), 421–431. doi:10.1038/cdd.2017.177

1092 Buechler, C., Pohl, R., & Aslanidis, C. (2017). Pro-Resolving Molecules–New Approaches to Treat Sepsis? International Journal of Molecular Sciences, 18(3), 476. doi:10.3390/ijms18030476

1093 Sierra, S., Lara-Villoslada, F., Comalada, M., Olivares, M., & Xaus, J. (2006). Dietary fish oil n–3 fatty acids increase regulatory cytokine production and exert anti-inflammatory effects in two murine models of inflammation. Lipids, 41(12), 1115–1125. doi:10.1007/s11745-006-5061-2

1094 Lachance, C., Segura, M., Dominguez-Punaro, M. C., Wojewodka, G., De Sanctis, J. B., Radzioch, D., & Gottschalk, M. (2014). Deregulated Balance of Omega-6 and Omega- 3 Polyunsaturated Fatty Acids following Infection by the Zoonotic Pathogen Streptococcus suis. Infection and Immunity, 82(5), 1778–1785. doi:10.1128/iai.01524-13

1095 Bagga, D., Wang, L., Farias-Eisner, R., Glaspy, J. A., & Reddy, S. T. (2003). Differential effects of prostaglandin derived from -6 and -3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proceedings of the National Academy of Sciences, 100(4), 1751–1756. doi:10.1073/pnas.0334211100

1096 Lee, T. H., Hoover, R. L., Williams, J. D., Sperling, R. I., Ravalese, J., Spur, B. W., … Austen, K. F. (1985). Effect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on in Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function. New England Journal of Medicine, 312(19), 1217–1224. doi:10.1056/nejm198505093121903

1097 Endres, S., Ghorbani, R., Kelley, V. E., Georgilis, K., Lonnemann, G., van der Meer, J. W. M., … Dinarello, C. A. (1989). The Effect of Dietary Supplementation with n–3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells. New England Journal of Medicine, 320(5), 265–271. doi:10.1056/nejm198902023200501

1098 Sperling, R. I., Benincaso, A. I., Knoell, C. T., Larkin, J. K., Austen, K. F., & Robinson, D. R. (1993). Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. Journal of Clinical Investigation, 91(2), 651–660. doi:10.1172/jci116245

1099 Caughey, G. E., Mantzioris, E., Gibson, R. A., Cleland, L. G., & James, M. J. (1996). The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. The American Journal of Clinical Nutrition, 63(1), 116–122. doi:10.1093/ajcn/63.1.116

1100 Rees, D., Miles, E. A., Banerjee, T., Wells, S. J., Roynette, C. E., Wahle, K. W., & Calder, P. C. (2006). Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. The American Journal of Clinical Nutrition, 83(2), 331–342. doi:10.1093/ajcn/83.2.331

1101 Meydani, S. N., Endres, S., Woods, M. M., Goldin, B. R., Soo, C., Morrill-Labrode, A., … Gorbach, S. L. (1991). Oral (n-3) Fatty Acid Supplementation Suppresses Cytokine Production and Lymphocyte Proliferation: Comparison between Young and Older Women. The Journal of Nutrition, 121(4), 547–555. doi:10.1093/jn/121.4.547

1102 von Schacky, C., Kiefl, R., Jendraschak, E., & Kaminski, W. E. (1993). n-3 fatty acids and cysteinyl-leukotriene formation in humans in vitro, ex vivo, and in vivo. The Journal of laboratory and clinical medicine, 121(2), 302–309.

1103 Gorjão, R., Verlengia, R., Lima, T. M. de, Soriano, F. G., Boaventura, M. F. C., Kanunfre, C. C., … Curi, R. (2006). Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function. Clinical Nutrition, 25(6), 923–938. doi:10.1016/j.clnu.2006.03.004

1104 Miles, E. A., Banerjee, T., Dooper, M. M. B. W., M’Rabet, L., Graus, Y. M. F., & Calder, P. C. (2004). The influence of different combinations of γ-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. British Journal of Nutrition, 91(6), 893–903. doi:10.1079/bjn20041131

1105 Gago-Dominguez, M., Jiang, X., & Castelao, J. E. (2007). Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis. Breast cancer research: BCR, 9(1), 201. URL: https://doi.org/10.1186/bcr1628

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1109 Barnard N с соавторами (2014) 'Saturated and trans fats and dementia: a systematic review', Neurobiology of Aging, Volume 35, Supplement 2, September 2014, Pages S65-S73.

1110 Pase CS с соавторами (2013) 'Influence of perinatal trans fat on behavioral responses and brain oxidative status of adolescent rats acutely exposed to stress', Neuroscience. 2013 Sep 5;247:242-52.

1111 Kinsella, J. E., Bruckner, G., Mai, J., & Shimp, J. (1981). Metabolism of trans fatty acids with emphasis on the effects of trans,trans-octadecadienoate on lipid composition, essential fatty acid, and prostaglandins: an overview. The American Journal of Clinical Nutrition, 34(10), 2307–2318. doi:10.1093/ajcn/34.10.2307

1112 Micha, R., & Mozaffarian, D. (2008). Trans fatty acids: Effects on cardiometabolic health and implications for policy. Prostaglandins, Leukotrienes and Essential Fatty Acids, 79(3–5), 147–152. doi:10.1016/j.plefa.2008.09.008

1113 Reiser Raymond (1973). "Saturated fat in the diet and serum cholesterol concentration: a critical examination of the literature" (PDF). Am J Clin Nutr. 26: 524–555.

1114 Nutrition Week Mar 22, 1991 21:12:2-3

1115 Zaloga, G. P., Harvey, K. A., Stillwell, W., & Siddiqui, R. (2006). TransFatty Acids and Coronary Heart Disease. Nutrition in Clinical Practice, 21(5), 505–512. doi:10.1177/0115426506021005505

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1864 Yang, S.-C., Tseng, C.-H., Wang, P.-W., Lu, P.-L., Weng, Y.-H., Yen, F.-L., & Fang, J.-Y. (2017). Pterostilbene, a Methoxylated Resveratrol Derivative, Efficiently Eradicates Planktonic, Biofilm, and Intracellular MRSA by Topical Application. Frontiers in Microbiology, 8. doi:10.3389/fmicb.2017.01103

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1866 Kouhpayeh, S., Shariati, L., Boshtam, M., Rahimmanesh, I., Mirian, M., Zeinalian, M., … Khanahmad, H. (2020). The Molecular Story of COVID-19; NAD+ Depletion Addresses All Questions in this Infection. doi:10.20944/preprints202003.0346.v1

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1869 Balandaykin, M. & Zmitrovich, I. (2015). Review on Chaga medicinal mushroom, Inonotus obliquus (Higher Basidiomycetes): Realm of medicinal applications and approaches on estimating its resource potential. International Journal of Medicinal Mushrooms 17 (2): 95–104.

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1875 Bao PP с соавторами (2012) 'Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the Shanghai Breast Cancer Survival Study', PLoS One. 2012;7(6):e39343.

1876 Boh, B. & Berovic, M. & Zhang, J. & Zhi-Bin, L. (2007). Ganoderma lucidum and its pharmaceutically active compounds. Biotechnology Annual Review 13: 265–301.

1877 Lin, Z. (2005). Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum. Journal of Pharmacological Sciences 99 (2): 144–153. Review.

1878 Dudhgaonkar, S. & Thyagarajan, A. & Sliva, D. (2009). Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. International immunopharmacology 9 (11): 1272–1280.

1879 Finimundy с соавторами (2014) A Review on General Nutritional Compounds and Pharmacological Properties of the Lentinula edodes Mushroom. Food and Nutrition Sciences, 5, 1095–1105.

1880 Dai, X. et al. (2015). Consuming Lentinula edodes (Shiitake) mushrooms daily improves human immunity: A randomized dietary intervention in healthy young adults. Journal of the American College of Nutrition 34 (6): 478–487.

1881 Hsieh с соавторами (2002). Effects of extracts of Coriolus versicolor (I'm-Yunity™) on cellcycle progression and expression of interleukins-1β,-6, and-8 in Promyelocytic HL-60 leukemic cells and mitogenically stimulated and nonstimulated human lymphocytes. The Journal of Alternative & Complementary Medicine 8 (5): 591–602.

1882 Torkelson, C. et al. (2012). Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncology 2012: 251632.

1883 Janjušević, L. et al. (2017). The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. Journal of Enzyme Inhibition and Medicinal Chemistry 32 (1): 355–362.

1884 Blagodatski, A. et al. (2018). Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy. Oncotarget 9 (49): 29259–29274.

1885 Lu, H. et al. (2011). TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy. Clinical Cancer Research 17 (21): 6742–6753.

1886 Matijašević, D. et al. (2016). The Antibacterial Activity of Coriolus versicolor Methanol Extract and Its Effect on Ultrastructural Changes of Staphylococcus aureus and Salmonella Enteritidis. Frontiers in Microbiology 7: 1226.

1887 Davis, L. & Kuttan, G. (2002). Effect of Withania somnifera on cell mediated immune responses in mice. Journal of Experimental & Clinical Cancer Research 21 (4): 585–590.

1888 Malik, F. et al. (2007). A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice. Life Sciences 80 (16): 1525–1538.

1889 Chandrasekhar, K. & Kapoor, J. & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration fullspectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine 34 (3): 255–262.

1890 Andrade с соавторами (2000). A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera. Indian Journal of Psychiatry 42 (3): 295–301.

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1893 Park с соавторами (2012). Potentiation of antioxidative and anti-inflammatory properties of cultured wild ginseng root extract through probiotic fermentation. Journal of Pharmacy and Pharmacology, 65(3), 457–464. doi:10.1111/jphp.12004

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1895 Ellis, J. M., & Reddy, P. (2002). Effects of Panax Ginseng on Quality of Life. Annals of Pharmacotherapy, 36(3), 375–379. doi:10.1345/aph.1a245

1896 Reay, J. L., Kennedy, D. O., & Scholey, A. B. (2005). Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. Journal of Psychopharmacology, 19(4), 357–365. doi:10.1177/0269881105053286

1897 Karuppiah, P., & Rajaram, S. (2012). Antibacterial effect of Allium sativum cloves and Zingiber officinale rhizomes against multiple-drug resistant clinical pathogens. Asian Pacific Journal of Tropical Biomedicine, 2(8), 597–601. doi:10.1016/s2221- 1691(12)60104-x

1898 Mashhadi, N. et al. (2013). Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. International Journal of Preventive Medicine 4 (Suppl 1): S36–S42.

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1901 Altman с соавторами (2001) 'Effects of a ginger extract on knee pain in patients with osteoarthritis', Arthritis Rheum. 2001 Nov;44(11):2531-8.

1902 Ozgoli, G., Goli, M., & Moattar, F. (2009). Comparison of Effects of Ginger, Mefenamic Acid, and Ibuprofen on Pain in Women with Primary Dysmenorrhea. The Journal of Alternative and Complementary Medicine, 15(2), 129–132. doi:10.1089/acm.2008.0311

1903 Zhu, J., Chen, H., Song, Z., Wang, X., & Sun, Z. (2018). Effects of Ginger (Zingiber officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine, 2018, 1–11. doi:10.1155/2018/5692962

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1905 Hewlings, S. & Kalman, D. (2017). Curcumin: A Review of Its' Effects on Human Health. Foods (Basel, Switzerland) 6 (10): 92.

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1907 Moghadamtousi, S. et al. (2014). A review on antibacterial, antiviral, and antifungal activity of curcumin. Biomed Research International 2014: 186864.

1908 Auyeung, K. & Han, Q. & Ko, J. (2016). Astragalus membranaceus: a review of its protection against inflammation and gastrointestinal cancers. The American Journal of Chinese Medicine 44 (01): 1–22.

1909 Brush, J. et al. (2006). The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Phytotherapy Research 20 (8): 687–695.

1910 Qin с соавторами (2012). Astragalus membranaceus extract activates immune response in macrophages via heparanase. Molecules (Basel, Switzerland) 17 (6): 7232–7240.

1911 Hosseinzadeh, H., & Nassiri-Asl, M. (2015). Pharmacological Effects of Glycyrrhizaspp. and Its Bioactive Constituents: Update and Review. Phytotherapy Research, 29(12), 1868–1886. doi:10.1002/ptr.5487

1912 Hajiaghamohammadi, A. A., Zargar, A., Oveisi, S., Samimi, R., & Reisian, S. (2016). To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori. The Brazilian Journal of Infectious Diseases, 20(6), 534–538. doi:10.1016/j.bjid.2016.07.015

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1915 Traboulsi, H., Cloutier, A., Boyapelly, K., Bonin, M.-A., Marsault, É., Cantin, A. M., & Richter, M. V. (2015). The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrobial Agents and Chemotherapy, 59(10), 6317–6327. doi:10.1128/aac.01098-15

1916 Traboulsi, H. et al. (2015). The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrobial Agents and Chemotherapy 59 (10): 6317–6327.

1917 Cinatl, J. et al. (2003). Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. The Lancet 361 (9374): 2045–2046.

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1919 Penn State Hershey Milton S. Hershey Medical Center. 'Licorice', Accessed Online: http://pennstatehershey.adam.com/content.aspx?productid=107&pid=33&gid=000262

1920 Cheng с соавторами (2013). Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice. Food and Chemical Toxicology, 55, 234–240. doi:10.1016/j.fct.2012.11.022

1921 Park, J. Y., & Kim, K. H. (2016). A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms. Climacteric, 19(6), 574–580. doi:10.1080/13697137.2016.1238453

1922 Zhang с соавторами (2017). The influence of Schisandrin B on a model of Alzheimer’s disease using β-amyloid protein Aβ1-42-mediated damage in SH-SY5Y neuronal cell line and underlying mechanisms. Journal of Toxicology and Environmental Health, Part A, 80(22), 1199–1205. doi:10.1080/15287394.2017.1367133

1923 Yan с соавторами (2016). The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice. Food & Function, 7(6), 2811–2819. doi:10.1039/c6fo00328a

1924 Coppin с соавторами (2013). Determination of flavonoids by LC/MS and anti-inflammatory activity in Moringa oleifera. Journal of Functional Foods, 5(4), 1892–1899. doi:10.1016/j.jff.2013.09.010

1925 Mbikay, M. (2012). Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review. Frontiers in Pharmacology, 3. doi:10.3389/fphar.2012.00024

1926 Chattopadhyay с соавторами (2010). Protective Role of Moringa oleifera (Sajina) Seed on Arsenic-Induced Hepatocellular Degeneration in Female Albino Rats. Biological Trace Element Research, 142(2), 200–212. doi:10.1007/s12011-010-8761-7

1927 Ouédraogo с соавторами (2013) 'Protective effect of Moringa oleifera leaves against gentamicin-induced nephrotoxicity in rabbits', Experimental and Toxicologic Pathology, Volume 65, Issue 3, March 2013, Pages 335–339.

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1958 Morselli, E., Maiuri, M. C., Markaki, M., Megalou, E., Pasparaki, A., Palikaras, K., Criollo, A., Galluzzi, L., Malik, S. A., Vitale, I., Michaud, M., Madeo, F., Tavernarakis, N., & Kroemer, G. (2010). Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell death & disease, 1(1), e10. URL: https://doi.org/10.1038/cddis.2009.8

1959 Narita с соавторами (2011) 'Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes', Science 20 May 2011: Vol. 332, Issue 6032, pp. 966–970, DOI: 10.1126/science.1205407

1960 García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., Sandri, M., & Muñoz-Cánoves, P. (2016). Autophagy maintains stemness by preventing senescence. Nature, 529(7584), 37–42. URL: https://doi.org/10.1038/nature16187

1961 Jiao, J., & Demontis, F. (2017). Skeletal muscle autophagy and its role in sarcopenia and organismal aging. Current opinion in pharmacology, 34, 1–6. URL: https://doi.org/10.1016/j.coph.2017.03.009

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1964 Shi, L., Zhang, T., Zhou, Y., Zeng, X., Ran, L., Zhang, Q., Zhu, J., & Mi, M. (2015). Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway. Endocrine, 50(2), 378–389. URL: https://doi.org/10.1007/s12020-015-0599-5

1965 Takagi, A., Kume, S., Kondo, M. et al. Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation. Sci Rep 6, 18944 (2016). URL: https://doi.org/10.1038/srep18944

1966 Korolchuk, V. I., Miwa, S., Carroll, B., & von Zglinicki, T. (2017). Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?. EBioMedicine, 21, 7–13. URL: https://doi.org/10.1016/j.ebiom.2017.03.020

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1968 Malaquin с соавторами (2016) 'Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype', Experimental Gerontology, Volume 82, September 2016, Pages 39–49.

1969 Fukushima, Y., Minato, N. & Hattori, M. The impact of senescence-associated T cells on immunosenescence and age-related disorders. Inflamm Regener 38, 24 (2018). URL: https://doi.org/10.1186/s41232-018-0082-9

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1971 Lee с соавторами (2019) 'Senescent T Cells Predict the Development of Hyperglycemia in Humans', Diabetes 2019 Jan; 68(1): 156–162., URL: https://doi.org/10.2337/db17-1218

1972 Covre с соавторами (2019) 'Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis', Front. Immunol., 04 January 2019 | URL: https://doi.org/10.3389/fimmu.2018.03001

1973 Pantsulaia с соавторами (2016) 'Senescent endothelial cells: Potential modulators of immunosenescence and ageing', Ageing Research Reviews, Volume 29, August 2016, Pages 13–25.

1974 Gnani, D, Crippa, S, della Volpe, L, et al. An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program. Aging Cell. 2019; 18:e12933. URL: https://doi.org/10.1111/acel.12933

1975 Ogrodnik с соавторами (2019) 'Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis', Cell Metabolism, Volume 29, Issue 5, 7 May 2019, Pages 1061–1077.e8

1976 URL: https://www.nature.com/articles/s41467-018-07825-3

1977 Linton с соавторами (2006) 'T cell function in the aged: Lessons learned from animal models', Clinical and Applied Immunology Reviews, Volume 6, Issue 2, March–April 2006, Pages 73-97

1978 Hadrup, S. R., Strindhall, J., Køllgaard, T., Seremet, T., Johansson, B., Pawelec, G., thor Straten, P., & Wikby, A. (2006). Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. Journal of immunology (Baltimore, Md.: 1950), 176(4), 2645–2653. URL: https://doi.org/10.4049/jimmunol.176.4.2645

1979 Lefebvre, J. S., Maue, A. C., Eaton, S. M., Lanthier, P. A., Tighe, M., & Haynes, L. (2012). The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice. Aging cell, 11(5), 732–740. URL: https://doi.org/10.1111/j.1474–9726.2012.00836.x

1980 Mocchegiani, E., & Malavolta, M. (2004). NK and NKT cell functions in immunosenescence. Aging cell, 3(4), 177–184. URL: https://doi.org/10.1111/j.1474–9728.2004.00107.x

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1982 Murciano, C., Villamón, E., Yáñez, A., O'Connor, J. E., Gozalbo, D., & Gil, M. L. (2006). Impaired immune response to Candida albicans in aged mice. Journal of medical microbiology, 55(Pt 12), 1649–1656. URL: https://doi.org/10.1099/jmm.0.46740-0

1983 Kuilman с соавторами (2008) 'Oncogene-Induced Senescence Relayed by an InterleukinDependent Inflammatory Network', Cell, VOLUME 133, ISSUE 6, P1019-1031, JUNE 13, 2008, DOI: URL: https://doi.org/10.1016/j.cell.2008.03.039

1984 Jiang, H., Ju, Z., & Rudolph, K. L. (2007). Telomere shortening and ageing. Zeitschrift fur Gerontologie und Geriatrie, 40(5), 314–324. URL: https://doi.org/10.1007/s00391-007-0480-0

1985 d'Adda di Fagagna F. (2008). Living on a break: cellular senescence as a DNA-damage response. Nature reviews. Cancer, 8(7), 512–522. URL: https://doi.org/10.1038/nrc2440

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1987 Kitada, K., Nakano, D., Ohsaki, H., Hitomi, H., Minamino, T., Yatabe, J., Felder, R. A., Mori, H., Masaki, T., Kobori, H., & Nishiyama, A. (2014). Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. Journal of diabetes and its complications, 28(5), 604–611. URL: https://doi.org/10.1016/j.jdiacomp.2014.05.010

1988 Zhang, P., Wang, Q., Nie, L., Zhu, R., Zhou, X., Zhao, P., Ji, N., Liang, X., Ding, Y., Yuan, Q., & Wang, Q. (2019). Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation. The Journal of biological chemistry, 294(49), 18807–18819. URL: https://doi.org/10.1074/jbc.RA119.010648

1989 Prattichizzo с соавторами (2018) 'Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages', Redox Biology, Volume 15, May 2018, Pages 170–181.

1990 Laberge, R. M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., Limbad, C., Demaria, M., Li, P., Hubbard, G. B., Ikeno, Y., Javors, M., Desprez, P. Y., Benz, C. C., Kapahi, P., Nelson, P. S., … Campisi, J. (2015). MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nature cell biology, 17(8), 1049–1061. URL: https://doi.org/10.1038/ncb3195

1991 Bourgeois, B. and Madl, T. (2018), Regulation of cellular senescence via the FOXO4- p53 axis. FEBS Lett, 592: 2083–2097. doi:10.1002/1873-3468.13057

1992 Baar, M. P., Brandt, R., Putavet, D. A., Klein, J., Derks, K., Bourgeois, B., Stryeck, S., Rijksen, Y., van Willigenburg, H., Feijtel, D. A., van der Pluijm, I., Essers, J., van Cappellen, W. A., van IJcken, W. F., Houtsmuller, A. B., Pothof, J., de Bruin, R., Madl, T., Hoeijmakers, J., Campisi, J., … de Keizer, P. (2017). Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell, 169(1), 132–147.e16. URL: https://doi.org/10.1016/j.cell.2017.02.031

1993 Imae, M., Fu, Z., Yoshida, A., Noguchi, T., & Kato, H. (2003). Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. Journal of molecular endocrinology, 30(2), 253–262. URL: https://doi.org/10.1677/jme.0.0300253

1994 Duan (2013) 'Sirtuins: from metabolic regulation to brain aging', Front. Aging Neurosci., 23 July 2013 | URL: https://doi.org/10.3389/fnagi.2013.00036

1995 Palacios, O. M., Carmona, J. J., Michan, S., Chen, K. Y., Manabe, Y., Ward, J. L., 3rd, Goodyear, L. J., & Tong, Q. (2009). Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging, 1(9), 771–783. URL: https://doi.org/10.18632/aging.100075

1996 Ropelle с соавторами (2009) 'Acute exercise modulates the Foxo1/PGC-1α pathway', J Physiol 587.9 (2009) pp 2069–2076.

1997 Sanchez A. M. (2015). FoxO transcription factors and endurance training: a role for FoxO1 and FoxO3 in exercise-induced angiogenesis. The Journal of physiology, 593(2), 363–364. URL: https://doi.org/10.1113/jphysiol.2014.285999

1998 Powers, S. K., & Jackson, M. J. (2008). Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiological reviews, 88(4), 1243–1276. URL: https://doi.org/10.1152/physrev.00031.2007

1999 Donovan, M. R., & Marr, M. T., 2nd (2016). dFOXO Activates Large and Small Heat Shock Protein Genes in Response to Oxidative Stress to Maintain Proteostasis in Drosophila. The Journal of biological chemistry, 291(36), 19042–19050. URL: https://doi.org/10.1074/jbc.M116.723049

2000 Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., Newgard, C. B., Farese, R. V., Jr, de Cabo, R., Ulrich, S., Akassoglou, K., & Verdin, E. (2013). Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, N.Y.), 339(6116), 211–214. URL: https://doi.org/10.1126/science.1227166

2001 Han с соавторами (2018) 'β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4', Cell, VOLUME 71, ISSUE 6, P1064-1078.E5, SEPTEMBER 20, 2018, DOI: URL: https://doi.org/10.1016/j.molcel.2018.07.036

2002 Pesheva (2019) 'Exercise, fasting help cells shed defective proteins', The Harvard Gazette, HEALTH & MEDICINE, Accessed Online: URL: https://news.harvard.edu/gazette/story/2019/02/exercise-fasting shown-to-help-cellsshed-defective-proteins/

2003 Rojas-Morales с соавторами (2019) 'Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury', Free Radical Biology and Medicine, Volume 135, 1 May 2019, Pages 60–67.

2004 Minuzzi, L. G., Rama, L., Chupel, M. U., Rosado, F., Dos Santos, J. V., Simpson, R., Martinho, A., Paiva, A., & Teixeira, A. M. (2018). Effects of lifelong training on senescence and mobilization of T lymphocytes in response to acute exercise. Exercise immunology review, 24, 72–84.

2005 He, C., Sumpter, R., Jr, & Levine, B. (2012). Exercise induces autophagy in peripheral tissues and in the brain. Autophagy, 8(10), 1548–1551. URL: https://doi.org/10.4161/auto.21327

2006 Penke, B., Bogár, F., Crul, T., Sántha, M., Tóth, M. E., & Vígh, L. (2018). Heat Shock Proteins and Autophagy Pathways in Neuroprotection: from Molecular Bases to Pharmacological Interventions. International journal of molecular sciences, 19(1), 325. URL: https://doi.org/10.3390/ijms19010325

2007 Nonn, L., Peng, L., Feldman, D., & Peehl, D. M. (2006). Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D. Cancer research, 66(8), 4516–4524. URL: https://doi.org/10.1158/0008-5472.CAN-05-3796

2008 Winzen, R. (1999). The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. The EMBO Journal, 18(18), 4969–4980. doi:10.1093/emboj/18.18.4969

2009 Shah, N. C., Shah, G. J., Li, Z., Jiang, X. C., Altura, B. T., & Altura, B. M. (2014). Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging. International journal of clinical and experimental medicine, 7(3), 497–514.

2010 Bienkowski (2015) 'Heavy Metal May Age Cells Prematurely', Scientific American, Environmental Health News, January 6, 2015, Accessed Online: URL: https://www.scientificamerican.com/article/heavy-metal-may-age-cells-prematurely/

2011 Song, Y., Leonard, S. W., Traber, M. G., & Ho, E. (2009). Zinc Deficiency Affects DNA Damage, Oxidative Stress, Antioxidant Defenses, and DNA Repair in Rats. The Journal of Nutrition, 139(9), 1626–1631. doi:10.3945/jn.109.106369

2012 Sharif, R., Thomas, P., Zalewski, P. and Fenech, M. (2015), Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status. Mol. Nutr. Food Res., 59: 1200–1212. doi:10.1002/mnfr.201400784

2013 Song, Y., Leonard, S. W., Traber, M. G., & Ho, E. (2009). Zinc Deficiency Affects DNA Damage, Oxidative Stress, Antioxidant Defenses, and DNA Repair in Rats. The Journal of Nutrition, 139(9), 1626–1631. doi:10.3945/jn.109.106369

2014 DiNicolantonio, J. J., Mangan, D., & O'Keefe, J. H. (2018). Copper deficiency may be a leading cause of ischaemic heart disease. Open heart, 5(2), e000784. URL: https://doi.org/10.1136/openhrt-2018-000784

2015 Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015). Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nature medicine, 21(12), 1424–1435. URL: https://doi.org/10.1038/nm.4000

2016 Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., Proctor, C., Correia-Melo, C., Victorelli, S., Fielder, E., Berlinguer-Palmini, R., Owens, A., Greaves, L. C., Kolsky, K. L., Parini, A., Douin-Echinard, V., … Passos, J. F. (2019). Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. The EMBO journal, 38(5), e100492. URL: https://doi.org/10.15252/embj.2018100492

2017 Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., & Mattson, M. P. (2019). Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nature neuroscience, 22(5), 719–728. URL: https://doi.org/10.1038/s41593-019-0372-9

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2052 Hosogi, S., Kusuzaki, K., Inui, T., Wang, X., & Marunaka, Y. (2014). Cytosolic chloride ion is a key factor in lysosomal acidification and function of autophagy in human gastric cancer cell. Journal of cellular and molecular medicine, 18(6), 1124–1133. URL: https://doi.org/10.1111/jcmm.12257

2053 Lee, H. K., Lund, J. M., Ramanathan, B., Mizushima, N., & Iwasaki, A. (2007). Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (New York, N.Y.), 315(5817), 1398–1401. URL: https://doi.org/10.1126/science.1136880

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2058 Shi, C. S., Shenderov, K., Huang, N. N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012). Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nature immunology, 13(3), 255–263. URL: https://doi.org/10.1038/ni.2215

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2063 Cheong H. (2015). Integrating autophagy and metabolism in cancer. Archives of pharmacal research, 38(3), 358–371. URL: https://doi.org/10.1007/s12272-015-0562-2

2064 Catalano, M., D'Alessandro, G., Lepore, F., Corazzari, M., Caldarola, S., Valacca, C., Faienza, F., Esposito, V., Limatola, C., Cecconi, F., & Di Bartolomeo, S. (2015). Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells. Molecular oncology, 9(8), 1612–1625. URL: https://doi.org/10.1016/j.molonc.2015.04.016

2065 Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, et al. Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest 2013; 123: 5319–5333.

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2068 Nakagawa, I., Amano, A., Mizushima, N., Yamamoto, A., Yamaguchi, H., Kamimoto, T., Nara, A., Funao, J., Nakata, M., Tsuda, K., Hamada, S., & Yoshimori, T. (2004). Autophagy defends cells against invading group A Streptococcus. Science (New York, N.Y.), 306(5698), 1037–1040. URL: https://doi.org/10.1126/science.1103966

2069 Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004). Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell, 119(6), 753–766. URL: https://doi.org/10.1016/j.cell.2004.11.038

2070 Birmingham, C. L., Smith, A. C., Bakowski, M. A., Yoshimori, T., & Brumell, J. H. (2006). Autophagy controls Salmonella infection in response to damage to the Salmonellacontaining vacuole. The Journal of biological chemistry, 281(16), 11374–11383. URL: https://doi.org/10.1074/jbc.M509157200

2071 Py, B. F., Lipinski, M. M., & Yuan, J. (2007). Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection. Autophagy, 3(2), 117–125. URL: https://doi.org/10.4161/auto.3618

2072 Gutierrez, M. G., Saka, H. A., Chinen, I., Zoppino, F. C., Yoshimori, T., Bocco, J. L., & Colombo, M. I. (2007). Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae. Proceedings of the National Academy of Sciences of the United States of America, 104(6), 1829–1834. URL: https://doi.org/10.1073/pnas.0601437104

2073 Tan, Y. K., Kusuma, C. M., St John, L. J., Vu, H. A., Alibek, K., & Wu, A. (2009). Induction of autophagy by anthrax lethal toxin. Biochemical and biophysical research communications, 379(2), 293–297. URL: https://doi.org/10.1016/j.bbrc.2008.12.048

2074 Terebiznik, M. R., Raju, D., Vázquez, C. L., Torbricki, K., Kulkarni, R., Blanke, S. R., Yoshimori, T., Colombo, M. I., & Jones, N. L. (2009). Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy, 5(3), 370–379. URL: https://doi.org/10.4161/auto.5.3.7663

2075 Sinha, S., Colbert, C. L., Becker, N., Wei, Y., & Levine, B. (2008). Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11. Autophagy, 4(8), 989–997. URL: https://doi.org/10.4161/auto.6803

2076 Zhou, D., & Spector, S. A. (2008). Human immunodeficiency virus type-1 infection inhibits autophagy. AIDS (London, England), 22(6), 695–699. URL: https://doi.org/10.1097/QAD.0b013e3282f4a836

2077 Chaumorcel, M., Souquère, S., Pierron, G., Codogno, P., & Esclatine, A. (2008). Human cytomegalovirus controls a new autophagy-dependent cellular antiviral defense mechanism. Autophagy, 4(1), 46–53. URL: https://doi.org/10.4161/auto.5184

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2080 Ait-Goughoulte, M., Kanda, T., Meyer, K., Ryerse, J. S., Ray, R. B., & Ray, R. (2007). Hepatitis C Virus Genotype 1a Growth and Induction of Autophagy. Journal of Virology, 82(5), 2241–2249. doi:10.1128/jvi.02093-07

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2083 Shi, J., Wong, J., Piesik, P., Fung, G., Zhang, J., Jagdeo, J., … Luo, H. (2013). Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling. Autophagy, 9(10), 1591–1603. doi:10.4161/auto.26059

2084 Maier, H., & Britton, P. (2012). Involvement of Autophagy in Coronavirus Replication. Viruses, 4(12), 3440–3451. doi:10.3390/v4123440

2085 Cottam, E. M., Whelband, M. C., & Wileman, T. (2014). Coronavirus NSP6 restricts autophagosome expansion. Autophagy, 10(8), 1426–1441. doi:10.4161/auto.29309

2086 Gassen, N. C., Niemeyer, D., Muth, D., Corman, V. M., Martinelli, S., Gassen, A., … Rein, T. (2019). SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nature Communications, 10(1). doi:10.1038/s41467-019-13659-4

2087 Heaton, N. S., & Randall, G. (2010). Dengue Virus-Induced Autophagy Regulates Lipid Metabolism. Cell Host & Microbe, 8(5), 422–432. doi:10.1016/j.chom.2010.10.006

2088 Racanelli, A. C., Kikkers, S. A., Choi, A. M. K., & Cloonan, S. M. (2018). Autophagy and inflammation in chronic respiratory disease. Autophagy, 14(2), 221–232. doi:10.1080/15548627.2017.1389823

2089 Racanelli, A. C., Kikkers, S. A., Choi, A., & Cloonan, S. M. (2018). Autophagy and inflammation in chronic respiratory disease. Autophagy, 14(2), 221–232. URL: https://doi.org/10.1080/15548627.2017.1389823

2090 Luciani, A., Villella, V. R., Esposito, S., Brunetti-Pierri, N., Medina, D., Settembre, C., Gavina, M., Pulze, L., Giardino, I., Pettoello-Mantovani, M., D'Apolito, M., Guido, S., Masliah, E., Spencer, B., Quaratino, S., Raia, V., Ballabio, A., & Maiuri, L. (2010). Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nature cell biology, 12(9), 863–875. URL: https://doi.org/10.1038/ncb2090

2091 Abdulrahman, B. A., Khweek, A. A., Akhter, A., Caution, K., Kotrange, S., Abdelaziz, D. H., Newland, C., Rosales-Reyes, R., Kopp, B., McCoy, K., Montione, R., Schlesinger, L. S., Gavrilin, M. A., Wewers, M. D., Valvano, M. A., & Amer, A. O. (2011). Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy, 7(11), 1359–1370. URL: https://doi.org/10.4161/auto.7.11.17660

2092 Mi, S., Li, Z., Yang, H. Z., Liu, H., Wang, J. P., Ma, Y. G., Wang, X. X., Liu, H. Z., Sun, W., & Hu, Z. W. (2011). Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms. Journal of immunology (Baltimore, Md.: 1950), 187(6), 3003–3014. URL: https://doi.org/10.4049/jimmunol.1004081

2093 Monick, M. M., Powers, L. S., Walters, K., Lovan, N., Zhang, M., Gerke, A., Hansdottir, S., & Hunninghake, G. W. (2010). Identification of an autophagy defect in smokers' alveolar macrophages. Journal of immunology (Baltimore, Md.: 1950), 185(9), 5425–5435. URL: https://doi.org/10.4049/jimmunol.1001603

2094 Ryter, S. W., Lee, S. J., & Choi, A. M. (2010). Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. Expert review of respiratory medicine, 4(5), 573–584. URL: https://doi.org/10.1586/ers.10.61

2095 Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004). Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell, 119(6), 753–766. URL: https://doi.org/10.1016/j.cell.2004.11.038

2096 Singh, S. B., Davis, A. S., Taylor, G. A., & Deretic, V. (2006). Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science (New York, N.Y.), 313(5792), 1438–1441. URL: https://doi.org/10.1126/science.1129577

2097 Parkhitko, A., Myachina, F., Morrison, T. A., Hindi, K. M., Auricchio, N., Karbowniczek, M., Wu, J. J., Finkel, T., Kwiatkowski, D. J., Yu, J. J., & Henske, E. P. (2011). Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent. Proceedings of the National Academy of Sciences of the United States of America, 108(30), 12455–12460. URL: https://doi.org/10.1073/pnas.1104361108

2098 Lee, H. K., Lund, J. M., Ramanathan, B., Mizushima, N., & Iwasaki, A. (2007). Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (New York, N.Y.), 315(5817), 1398–1401. URL: https://doi.org/10.1126/science.1136880

2099 Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B. G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., Tanaka, K., Kawai, T., Tsujimura, T., Takeuchi, O., Yoshimori, T., & Akira, S. (2008). Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature, 456(7219), 264–268. URL: https://doi.org/10.1038/nature07383

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